Table 1.
IC50 against NRC-03-nhCoV, CC50 on Vero-E6, and the selectivity index (SI) [CC50/IC50] of the target compounds.
| Compound ID | R | IC50a (μM) | CC50b (μM) | SIc |
|---|---|---|---|---|
| 11a | 2-COOH | 104 | 450.5 | 4.3 |
| 11b | 3-COOH | 79.7 | 394 | 4.9 |
| 11c | 4-COOH | 79.2 | 442.6 | 5.6 |
| 12a | 2-COOH | 173.6 | 431.4 | 2.5 |
| 12b | 3-COOH | 531.3 | 524.3 | 0.98 |
| 12c | 4-COOH | 530.4 | 333.5 | 0.63 |
| 17a | H | 317.5 | 186.4 | 0.59 |
| 17b | 4-Me | 126.7 | 271.4 | 2.14 |
| 17c | 4-NO2 | 121.1 | 316.1 | 2.61 |
| 17d | 2-OMe | 258.8 | 101.2 | 0.4 |
| 17e | 2-Cl | 457.8 | 114.2 | 0.24 |
| 17f | 4-Cl | 74.3 | 319 | 4.3 |
| 17g | 2-Br | 21.4 | 184.9 | 8.64 |
| 18a | H | 140.2 | 235 | 1.68 |
| 18b | 4-Me | 113.7 | 503.8 | 4.43 |
| 18c | 4-NO2 | 38.45 | 410.3 | 10.67 |
| 18d | 2-OMe | 107 | 315.5 | 2.95 |
| 18e | 2-Cl | 459.8 | 524.5 | 1.14 |
| 18f | 4-Cl | 26.4 | 423.6 | 16.04 |
| 18g | 2-Br | 93.4 | 488.8 | 5.23 |
aIC50 (half maximal inhibitory concentration); bCC50 (half maximal cytotoxic concentration); cSI (Selectivity index).