Figure 1. Disease Event Clinical Syndromes.

A total of 136 disease events were reported in 75 patients presenting with MOG-antibody–associated disorders (panel A). Presentation with acute disseminated encephalomyelitis (ADEM) was more common in patients aged 8 years or younger at onset (p = 0.002) while presentation with optic neuritis was more common in patients older than 8 years (p = 0.001). Data on time to treatment at first disease event were available in 69/75 patients; the subgroup of patients receiving immunotherapy <7 days of initial symptom onset (panel B) were less likely to follow a relapsing disease course compared with those not receiving any immunotherapy <7 days of symptom onset (panel C) (p = 0.002). LETM, longitudinally extensive transverse myelitis; NMOSD, neuromyelitis optica spectrum disorder.