Figure 6. Identification of Brain Inflammatory Networks During EAE.

(A) Left: Uniform manifold approximation and projection (UMAP) from merged data of CD31-selected cells and infiltrated cells from EAE mice. Right: Proportions of immune subsets in EAE mice. (B) Dot plot summarizing probability of interaction for molecular pairs involved in potential cell-cell contact interactions. (C) Dot plot summarizing probability of interaction for molecular pairs involved in potential cell interactions from immune subsets targeting venous ECs through secreted signaling. (D) Circos plot showing the specific cell type and the directionality of the interaction pathways involving adhesion molecules and secreted cytokines used by immune cells and EC subtypes. Abbreviation: EAE = experimental autoimmune encephalomyelitis.