Table 2.

Functional pathways and categories included in the top enriched pathway in Fig. 1e

Categories	Diseases or functions annotation	P value	Molecules	# Molecules
Cell-to-cell signaling and interaction, cellular movement, hematological system development and function, immune cell trafficking, inflammatory response	Recruitment of macrophages	0.0000252	CD8A, ICAM1, NOTCH1, RHOB	4
Cell-to-cell signaling and interaction	Adhesion of breast cancer cell lines	0.000206	CTNND1, ICAM1, SACM1L	3
Cell-to-cell signaling and interaction, cellular movement, hematological system development and function, immune cell trafficking, inflammatory response	Adhesion of macrophages	0.00091	ICAM1, RHOB	2
Cancer, cell-to-cell signaling and interaction, organismal injury and abnormalities	Adhesion of myelomonocytic cells	0.00124	ICAM1	1
Cancer, cell-to-cell signaling and interaction, organismal injury and abnormalities	Activation of tumor cells	0.0013	CTNND1, NOTCH1	2
Cell-to-cell signaling and interaction	Adhesion of connective tissue cells	0.00191	ATP6AP1, ICAM1, RHOB	3
Cancer, cell-to-cell signaling and interaction, organismal injury and abnormalities	Activation of mammary tumor cells	0.00248	CTNND1	1
Cell-mediated immune response, cell-to-cell signaling and interaction, cellular movement, hematological system development and function, immune cell trafficking	Adhesion of regulatory T lymphocytes	0.00248	ICAM1	1
Cell-to-cell signaling and interaction, cellular assembly and organization, hematological system development and function, hypersensitivity response, immune cell trafficking	Cell–cell adhesion of eosinophils	0.00248	ICAM1	1
Cancer, cell-to-cell signaling and interaction, organismal injury and abnormalities	Activation of leukemic blasts	0.00248	NOTCH1	1