Fig. 6. Accessory genes identified by pangenome analysis that might be associated with cef^Razi^R isolates and the outbreak strains.

a shows the accessory genes significantly associated with the cef^Razi^R phenotype. There were 92 genes screened by the chi-square test whose P values were lower than 1e-30 and defined as genes if their proportion was more than 80% in the cef^Razi^R group but less than 20% in non-cef^Razi^R isolates. b COG function classifications of significant accessory clusters of orthologous genes. Source data are provided as a Source Data file. cef^Razi^R coresistance to ceftriaxone and azithromycin, COG Cluster of Orthologous Groups.