Table 2.

Overview of work package 2 (WP2) hypotheses on pathophysiological mechanisms that might cause long COVID symptoms

Pathophysiological mechanism	Main research questions include, but are not limited to:	Cohort (minimally) involved
Thromboembolic complications	1. What is the impact of venous thromboembolic complications on long-term functional outcomes in COVID-19 survivors?	DC&TC
Cardiovascular diseases	2. What is the impact of myocardial damage during hospital ward or ICU stay due to COVID-19 on angina pectoris and dyspnoea over time?	CAPACITY-COVID
Endothelial dysfunction	3. What is the relationship between elevated inflammation parameters and persistent thrombo-inflammation, coagulation, microvascular and macrovascular dysfunction, and respiratory symptoms after COVID-19 disease?	COVAS
Multi organ failure	4. What is the impact of multiorgan failure during ICU stay on long-term functional outcomes and (health-related) quality of life in COVID-19 survivors?	MaastrICCht
Pre-existing coronary atherosclerosis	5. What is the relationship between pre-existing clinical and subclinical coronary atherosclerosis, angina pectoris and respiratory symptoms after COVID-19 infection?	ELVIS
NA	6. What is the level of functioning during the course of disease in patients following a rehabilitation programme after COVID-19-related ICU admission?	Adelante

CAPACITY-COVID, Cardiac complications in patients with COVID-19 cohorts; DC&TC cohort, Dutch COVID and Thrombosis Consortium cohort; COVAS, Bernhoven Early detection of Vascular damage after COVID-19 cohort; ELVIS, ZuydErLand COVID-19 regiStry; ICU, intensive care unit; MaastrICCht, Maastricht Intensive Care COVID cohort; NA, not applicable; POPCOrn, POPulation health impact of the COVID-19 pandemic.