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. 2022 Nov 25;15:2555–2565. doi: 10.2147/CCID.S385162

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© 2022 Markiewicz et al.

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The proposed systemic mechanisms of hyperpigmentation in dark skin. Dark skin demonstrates unique characteristics regarding epidermal morphogenesis, secretory activity in the dermis and the architecture of dermal-epidermal junctions that are distinctive from light skin. Dark skin is prone to the development of PIH, AD and melasma, which are all linked to inflammation. A predisposition to low-grade chronic inflammation and weaker macrovascular function has been also detected in dark-skinned individuals. Abnormal melanogenesis is furthermore exasperated by UVR; both the UVR-induced inflammation and cell senescence have been demonstrated to drive age-related hyperpigmentation.