TABLE 3.

Different estimates of hierarchical-based treatment effects of long-term DAPT in the NIPPON trial. Log and logit transformations are used for the WR and MW estimates, respectively, to improve behavior. The bootstrap approach used 100 bootstrap samples, while the permutation p-value is based on 1000 resamples

	WR			MW
Feature	PH	NPMLE	Simple	PH	NPMLE	Simple
Estimate	1.499	2.127	1.446	0.510	0.519	0.509
log(WR), logit(MW)	0.405	0.755	0.369	0.041	0.075	0.037
Bootstrap se	0.215	0.324	0.225	0.024	0.035	0.024
Wald p-value	0.060	0.020	0.100	0.088	0.030	0.116
Permutation p-value	0.072	0.012	0.112	0.065	0.011	0.109

Abbreviations: DAPT, dual antiplatelet therapy; MW, Mann-Whitney; NPMLE, nonparametric maximum likelihood estimator; PH, proportional hazards; WR, win ratio.