. 2022 Oct 27;62(22):5771–5779. doi: 10.1021/acs.jcim.2c00865

Table 1. Functional Properties of JWH-133 at Nonmutated and Mutated CB₂R.

	pEC₅₀^a	E_max^b
nonmutated	7.5 ± 0.1	47.0 ± 3.5
Val36^1.35Phe	6.8 ± 0.2	60.2 ± 6.7
Ala282^7.36Phe	6.5 ± 0.6	84.3 ± 8.4
Val36^1.35 Met	7.9 ± 0.1	56.7 ± 1.7
Ala282^7.36 Met	7.8 ± 0.2	45.4 ± 4.2

pEC₅₀ (nM).

E_max (%), the maximum inhibition of forskolin-stimulated cAMP levels (normalized to 100%). These values were calculated using nonlinear regression analysis. Data are expressed as the mean ± SE of at least nine independent experiments performed in triplicate.

Table 1. Functional Properties of JWH-133 at Nonmutated and Mutated CB2R.

Table 1. Functional Properties of JWH-133 at Nonmutated and Mutated CB₂R.