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. 2022 Oct 22;62(22):5568–5580. doi: 10.1021/acs.jcim.2c00934
  RDKit
Pros Very versatile and has numerous options in addition
  to purely conformational analysis
  Easy to automatize and include in workflows
  Multiple possible modifications (cutoffs, atomic
  charges, conformer generation method,
  symmetry, etc.)
Cons It is a library, not software per se, so it has to be
  scripted from scratch
  Learning curve more elevated than the rest