Skip to main content
. 2022 Oct 22;62(22):5568–5580. doi: 10.1021/acs.jcim.2c00934
  wSterimol
Pros Systematic conformer search ensures that with
  well-defined dihedrals, no conformer
  will be missing
  Graphical interface. Good for beginners and users
  not used to working with a terminal
  Energy optimization can be done directly in DFT
  (with Gaussian)
Cons Difficult to automatize. It is needed to input the
  atoms forming the rotatable dihedrals manually
  Fast energy growth: a few numbers of statistically
  relevant conformers