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. 2022 Oct 21;2(11):2381–2399. doi: 10.1021/jacsau.2c00292

Figure 15.

Figure 15

Autonomous synthesis with a DNA walker. (a) A DNA walker with “robotic arms” is capable of picking up different gold nanoparticles when traversing a programmed track with cargo-donating stations. AFM images show the change in nanoparticle arrangement at specific stages of the walker. Reproduced with permission from ref (155). Copyright 2010, Nature Publishing Group. (b) Sophisticated example of DNA-templated multistep synthesis programmed by a molecular walker. A DNAzyme-based walker modified with a primary amine is able to react with succinimidyl ester functionalized footholds to yield complex molecules. Reproduced with permission from ref (156). Copyright 2010, Nature Publishing Group. (c) Design and characterization of the enzyme pathway regulation system on DNA origami. Reproduced from ref (158). Copyright 2018, American Chemical Society.