Table 3.

Toxicity relevant symptom burden 30 days after CAR T-cell infusion

	Acute CRS							Acute ICANS
	Grade 0–1 (N=17)		Grade 2–4 (N=15)		95% CI			Grade 0–1 (N=20)		Grade 2–4 (N=12)			95% CI
	Mean	SD	Mean	SD	Effect size	Lower	Upper	Mean	SD	Mean	SD	Effect size	Lower	Upper
MDASI-Core items
Pain	1.59	2.85	1.6	2.69	0.00	−0.70	0.69	1.65	2.96	1.5	2.43	0.05	−0.66	0.77
Fatigue	2.94	2.79	4.07	2.74	−0.41	−1.10	0.30	2.8	2.86	4.58	2.35	−0.66	−1.38	0.09
Nausea	0.71	1.61	1.2	1.97	−0.27	−0.96	0.43	0.6	1.5	1.5	2.11	−0.51	−1.23	0.22
Sleep	2.76	3.03	2.4	2.8	0.12	−0.57	0.81	2.9	3.09	2.08	2.54	0.28	−0.44	0.99
Distress	1.82	2.51	1.27	1.83	0.25	−0.46	0.94	1.6	2.41	1.5	1.88	0.04	−0.67	0.76
Short breath	1.24	1.89	1.67	2.26	−0.21	−0.90	0.49	1.35	2.03	1.58	2.15	−0.11	−0.82	0.61
Remember	1.06	1.52	1.53	1.88	−0.28	−0.97	0.43	1.05	1.54	1.67	1.92	−0.37	−1.08	0.36
Appetite	1.41	2.43	3	3.34	−0.55	−1.24	0.17	1.4	2.6	3.42	3.18	−0.71	−1.43	0.04
Drowsy	2.18	2.83	3.87	3.36	−0.55	−1.24	0.17	2.35	3.01	4	3.25	−0.53	−1.25	0.21
Dry mouth	1.24	2.44	2.13	2.88	−0.34	−1.03	0.37	1.65	2.81	1.67	2.46	−0.01	−0.72	0.71
Sadness	0.71	1.53	1.53	2.5	−0.40	−1.09	0.31	1	1.86	1.25	2.42	−0.12	−0.83	0.60
Vomiting	0.29	0.77	0.87	2.13	−0.37	−1.06	0.34	0.25	0.72	1.08	2.35	−0.54	−1.25	0.20
Numbness	1.82	2.7	1	1.41	0.37	−0.34	1.06	1.3	2.41	1.67	1.87	−0.17	−0.88	0.55
MDASI-Interference Items
Activity	1.94	2.93	2.64	2.62	−0.25	−0.95	0.47	2.2	2.86	2.36	2.73	−0.06	−0.79	0.68
Mood	1.71	3.02	2	1.8	−0.11	−0.82	0.60	1.9	2.88	1.73	1.74	0.07	−0.67	0.80
Work	2	3.02	2.46	2.33	−0.17	−0.89	0.56	2	2.89	2.55	2.46	−0.20	−0.93	0.54
Relations	1.53	2.65	0.86	1.61	0.30	−0.42	1.00	1.4	2.5	0.91	1.7	0.22	−0.53	0.95
Walking	1.94	2.7	2.92	2.72	−0.36	−1.08	0.38	1.85	2.6	3.4	2.76	−0.58	−1.34	0.20
Enjoyment of life	1.76	2.95	3.07	2.76	−0.46	−1.16	0.27	1.75	2.77	3.45	2.91	−0.60	−1.34	0.16
CAR-T related Symptoms
Diarrhea	0.82	2.01	1.6	3.46	−0.28	−0.97	0.42	0.7	1.87	2	3.79	−0.48	−1.19	0.26
Inability to eat	0.76	2.05	1.2	2.14	−0.21	−0.90	0.49	0.6	1.85	1.58	2.35	−0.48	−1.19	0.26
Rash	0.41	1.18	0	0	0.48	−0.24	1.17	0.35	1.09	0	0	0.40	−0.33	1.12
Malaise	5	4.6	2.13	2.67	0.95	−0.33	2.15	1.4	2.19	2.67	2.74	−0.53	−1.24	0.21
Lack of energy	2.18	2.38	3.8	3.17	−0.58	−1.28	0.14	2	2.18	4.5	3.23	−0.96	−1.68	−0.18
Tremors	0.59	1.58	0.4	1.3	0.13	−0.57	0.82	0.5	1.47	0.5	1.45	0.00	−0.72	0.72
Muscle weakness	2.06	2.38	1.67	2.64	0.16	−0.54	0.85	1.7	2.27	2.17	2.86	−0.19	−0.90	0.53
Weakness	1.12	1.93	3.67	3.29	−0.96	−1.67	−0.21	1.5	2.69	3.67	2.87	−0.79	−1.51	−0.03
Fever	0.53	1.01	0.87	1.51	−0.27	−0.96	0.44	0.7	1.13	0.67	1.5	0.02	−0.69	0.74
Headache	1	2	1.07	2.43	−0.03	−0.73	0.66	0.8	1.85	1.42	2.68	−0.28	−0.99	0.44
Irritability	1.18	1.81	2	2.73	−0.36	−1.05	0.35	1.2	1.7	2.17	3.01	−0.43	−1.14	0.31
Balance	0.35	1	1.8	2.76	−0.72	−1.41	0.02	0.8	2.35	1.42	1.68	−0.29	−1.00	0.44
Mouth sore	0.35	1.22	0	0	0.39	−0.32	1.08	0.3	1.13	0	0	0.33	−0.39	1.05
Dizziness	0.59	1.7	1.8	2.81	−0.53	−1.22	0.19	0.45	1.57	2.33	2.93	−0.87	−1.59	−0.10
Difficulty Swallowing	0.06	0.24	0.73	2.34	−0.42	−1.11	0.30	0.05	0.22	0.92	2.61	−0.55	−1.26	0.19
Attention	1.82	2.38	1.67	2.35	0.06	−0.63	0.76	1.5	2.28	2.17	2.44	−0.29	−1.00	0.44
Bone aches	1.53	2.24	1.93	2.79	−0.16	−0.85	0.54	1.65	2.54	1.83	2.48	−0.07	−0.79	0.65
Heart bead	0.88	2.18	0.93	1.83	−0.02	−0.72	0.67	0.85	2.03	1	2	−0.07	−0.79	0.64
Swelling	0.65	1.17	1.07	2.69	−0.21	−0.90	0.49	0.3	0.73	1.75	2.99	−0.76	−1.48	0.00
Difficulty Speaking	0.12	0.33	1.87	3.16	−0.81	−1.51	−0.06	0.55	1.47	1.58	3.26	−0.45	−1.16	0.29
Coughing	1.65	2.37	2.93	3.37	−0.44	−1.14	0.27	1.8	2.33	3	3.67	−0.41	−1.13	0.32
Sexual function	1.24	2.56	2.29	3.83	−0.33	−1.03	0.39	1.2	2.61	2.64	4.01	−0.46	−1.19	0.30
Health Status and HRQoL
EQ5D-5L VAS scale*	81.6	18.9	68.1	23.6	0.63	−0.12	1.35	81.6	18.8	64.8	23.6	0.81	0.03	1.54
HRQoL*	8.35	1.69	7.4	1.68	0.56	−0.16	1.26	8.5	1.5	6.92	1.68	1.01	0.23	1.74
PROMIS-29 Domains and Pain rating
Physical function*	45.7	8.76	38.3	12.3	0.70	−0.03	1.40	46.5	10	35.1	8.99	1.18	0.38	1.92
Anxiety	45.6	8.73	48.3	8.07	−0.32	−1.01	0.39	45.5	8.4	49.1	8.24	−0.43	−1.14	0.30
Depression	51.9	2.18	51.3	1.85	0.30	−0.41	0.99	51.3	1.64	52	2.56	−0.35	−1.06	0.38
Fatigue	48.1	11.9	54.2	11	−0.53	−1.22	0.19	47.8	10.8	56.2	11.6	−0.76	−1.48	0.00
Sleep disturbance	49.5	8.1	51.8	7.68	−0.29	−0.98	0.41	50	8.72	51.4	6.47	−0.18	−0.89	0.55
Social roles*	53.2	8.46	46.1	9.08	0.81	0.07	1.51	51.3	10.1	47.5	7.72	0.41	−0.32	1.12
Pain interference	50.2	8.97	49.5	12	0.07	−0.63	0.76	49.7	10.4	50.2	10.7	−0.05	−0.76	0.67
Pain average	2.53	2.72	2.73	2.91	−0.07	−0.76	0.63	2.35	2.83	3.08	2.71	−0.26	−0.97	0.46

^{^}indicates ES>=0.5