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. 2022 Nov 30;22:196. doi: 10.1186/s12894-022-01141-1

Table 2.

The number of patients for each cancer type grouped by sex, variant type and pathogenicity

Factors Categories Cancer Types P values
BLCA KICH KIRC KIRP PRAD
Sex (%)
Female 10 (20.8) 2 (28.6) 25 (56.8) 9 (20.0) 0 ( 0.0) P = 0.00039(excl PRAD)
Male 38 (79.2) 5 (71.4) 19 (43.2) 36 (80.0) 62 (100.0) P < 0.001(incl PRAD)
Variant_Type (%)
stop_gained 22 (45.8) 0 ( 0.0) 12 (27.3) 14 (31.1) 18 (29.0) P = 0.37
frameshift_variant 10 (20.8) 4 (57.1) 14 (31.8) 14 (31.1) 25 (40.3)
missense_variant 11 (22.9) 2 (28.6) 13 (29.5) 10 (22.2) 10 (16.1)
Others 5 (10.5) 1 (14.3) 5 (11.4) 7 (15.6) 9 (14.5)
Pathogenicity (%)
Likely Pathogenic 13 (27.1) 2 (28.6) 8 (18.2) 14 (31.1) 15 (24.2) P = 0.74
NonPathogenic 18 (37.5) 3 (42.9) 22 (50.0) 19 (42.2) 33 (53.2)
Pathogenic 17 (35.4) 2 (28.6) 14 (31.8) 12 (26.7) 14 (22.6)
Number of patients 48 7 44 45 62