Table 2.
Predictors of seropositivity 14 to 142 days after receiving the second dose in health personnel vaccinated with BBIBP-CorV.
| Characteristics | 14–142 days post second dose |
Crude analysis |
Adjusted analysis |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
Negative |
Positive |
P valuea | cORb | 95%CIc | P value | aORd | 95%CIc | P value | ||
|
(n = 377) |
(n = 665) |
|||||||||
| n (%) | n (%) | |||||||||
| Sex | 0.200 | |||||||||
| Female | 267 (31.0%) | 495 (69.0%) | – | – | – | – | ||||
| Male | 110 (36.0%) | 170 (64.0%) | 0.80 | 0.61–1.04 | 0.091 | 0.82 | 0.58–1.17 | 0.300 | ||
| Age (years) | 0.001 | <0.001 | <0.001 | |||||||
| Mean (SD) | 47.5 (11.6) | 44.0 (11.6) | ||||||||
| Median (p25-p75) | 49.0 (36.0–57.3) | 43.0 (35.0–52.0) | ||||||||
| Range (minimum-maximum) | 25.0–69.0 | 24.0–70.0 | ||||||||
| Comorbidities | 0.200 | |||||||||
| None | 252 (31.1%) | 460 (68.9%) | – | – | – | – | ||||
| One or more | 125 (36.4%) | 205 (63.6%) | 0.79 | 0.60–1.03 | 0.086 | 0.96 | 0.68–1.35 | 0.800 | ||
| Previous SARS-CoV-2 infection | <0.001 | |||||||||
| No | 343 (49.9%) | 292 (50.1%) | – | – | – | – | ||||
| Yes | 34 (7.8%) | 373 (92.2%) | 11.7 | 8.00–17.2 | <0.001 | 11.7 | 7.81–17.5 | <0.001 | ||
| Profession | <0.001 | |||||||||
| Physician | 130 (46.3%) | 147 (53.7%) | – | – | – | – | ||||
| Administrative or other | 102 (32.9%) | 172 (67.1%) | 1.76 | 1.25–2.49 | 0.001 | 1.24 | 0.77–2.02 | 0.400 | ||
| Nurse | 100 (32.2%) | 178 (67.8%) | 1.82 | 1.24–2.66 | 0.002 | 1.53 | 0.91–2.58 | 0.110 | ||
| Nursing technician | 45 (15.6%) | 168 (84.4%) | 4.67 | 2.73–8.00 | <0.001 | 2.24 | 1.14–4.37 | 0.019 | ||
| Work modality | 0.017 | |||||||||
| Face-to-face/Mixed | 300 (30.7%) | 576 (69.3%) | – | – | – | – | ||||
| Non-attendance/Licensed | 77 (43.9%) | 89 (56.1%) | 0.57 | 0.40–0.80 | 0.001 | 0.94 | 0.58–1.51 | 0.800 | ||
| Work area | 0.089 | |||||||||
| Hospitalization/Surgery | 66 (30.3%) | 146 (69.7%) | – | – | – | – | ||||
| Administrative or other related | 56 (32.8%) | 94 (67.2%) | 0.89 | 0.58–1.35 | 0.600 | 0.61 | 0.36–1.03 | 0.065 | ||
| Diagnostic support or other related | 54 (38.4%) | 86 (61.6%) | 0.70 | 0.47–1.04 | 0.078 | 0.77 | 0.46–1.28 | 0.300 | ||
| Outpatient. extramural and other related | 81 (45.9%) | 102 (54.1%) | 0.51 | 0.32–0.81 | 0.005 | 0.83 | 0.48–1.42 | 0.500 | ||
| Critical care | 69 (36.1%) | 113 (63.9%) | 0.77 | 0.45–1.31 | 0.300 | 0.53 | 0.28–1.02 | 0.058 | ||
| Emergency or urgent care | 51 (26.2%) | 124 (73.8%) | 1.22 | 0.82–1.82 | 0.300 | 0.77 | 0.47–1.27 | 0.300 | ||
| Works in COVID-19 area | <0.001 | |||||||||
| No | 220 (39.0%) | 318 (61.0%) | – | – | – | – | ||||
| Yes | 157 (25.6%) | 347 (74.4%) | 1.86 | 1.44–2.40 | <0.001 | 1.47 | 1.02–2.11 | 0.040 | ||
| EsSalud hospital of work | >0.900 | |||||||||
| Edgardo Rebagliati Martins National Hospital | 155 (31.6%) | 298 (68.4%) | – | – | – | – | ||||
| Guillermo Almenara Irigoyen National Hospital | 70 (33.2%) | 114 (66.8%) | 0.93 | 0.67–1.29 | 0.700 | 0.87 | 0.57–1.32 | 0.500 | ||
| I Octavio Mongrut Muñoz Hospital/Villa Panamericana | 24 (33.9%) | 45 (66.1%) | 0.90 | 0.57–1.42 | 0.600 | 0.27 | 0.14–0.53 | <0.001 | ||
| Alberto Sabogal Sologuren National Hospital | 128 (33.5%) | 208 (66.5%) | 0.92 | 0.66–1.26 | 0.600 | 0.61 | 0.40–0.94 | 0.024 | ||
| Time since second dose (days) | 0.030 | <0.001 | <0.001 | |||||||
| Median (p25-p75) | 131.0 (124.0–134.0) | 130.0 (123.0–134.0) | ||||||||
| Range (minimum-maximum) | 14.0–142.0 | 14.0–142.0 | ||||||||
n: unweighted absolute frequency; %: weighted percentage.
The associations of seropositivity with age and time since second vaccination are shown in Fig. 1, Fig. 2.
a
Squared chi-square test with Rao and Scott second-order correction; Wilcoxon rank sum test for complex samples.
b
cOR: crude odds ratio.
c
CI: confidence interval.
d
aOR: adjusted odds ratio; SD: standard deviation.