Table 2.
Pharmacokinetic parameters in our eighteen patients
| Parameter | Valuea |
|---|---|
| Gefitinib | |
| AUC0–48 (μM h) | 9.49 ± 3.5 |
| AUC0–24 (μM h) | 6.17 ± 1.9 |
| CL/F (L/h) | 51.0 ± 25 |
| Tmax (h) | 4.56 ± 1.3 |
| Cmax (μM) | 0.492 ± 0.19 |
| t1/2 (h) | 24.1 ± 8.6 |
| O-desmethyl gefitinib | |
| AUC0–48 (μM h) | 10.6 ± 14 |
| AUC0–24 (μM h) | 5.16 ± 6.7 |
AUC0–48, area under the plasma concentration–time curve from 0 to 48 h; AUC0–24, area under the plasma concentration–time curve from 0 to 24 h; CL/F, clearance of the drug from plasma; Tmax, time to the maximum plasma concentration; Cmax, maximum plasma concentration; t1/2, the elimination half-life
aMean ± SD