Table 4.
Genotype and allele frequencies of polymorphisms in the CYP3A5, CYP2D6, ABCG2, ABCB1, and OATP1B1
| Genotype | Number (%) | Allele frequency | ||
|---|---|---|---|---|
| CYP3A5*3 | *1/*1 | 1 (0.06) | *1 | 0.22 |
| *1/*3 | 6 (0.33) | *3 | 0.78 | |
| *3/*3 | 11 (0.61) | |||
| CYP2D6*5 and *10 | *1/*1 | 4 (0.22) | *1 | 0.47 |
| *1/*5 | 1 (0.06) | *5 | 0.06 | |
| *1/*10 | 8 (0.44) | *10 | 0.47 | |
| *5/*10 | 1 (0.06) | |||
| *10/*10 | 4 (0.22) | |||
| ABCG2 421C > A | C/C | 8 (0.44) | C | 0.64 |
| C/A | 7 (0.39) | A | 0.36 | |
| A/A | 3 (0.17) | |||
| ABCB1 1236C > T | C/C | 4 (0.22) | C | 0.53 |
| C/T | 11 (0.61) | T | 0.47 | |
| T/T | 3 (0.17) | |||
| ABCB1 2677G > T/A | G/G | 1 (0.06) | G | 0.28 |
| G/T | 7 (0.38) | T | 0.61 | |
| G/A | 1 (0.06) | A | 0.11 | |
| T/T | 6 (0.33) | |||
| T/A | 3 (0.17) | |||
| ABCB1 3435C > T | C/C | 1 (0.06) | C | 0.25 |
| C/T | 7 (0.38) | T | 0.75 | |
| T/T | 10 (0.56) | |||
| OATP1B1 388A > G | A/A | 3 (0.17) | A | 0.36 |
| A/G | 7 (0.38) | G | 0.64 | |
| G/G | 8 (0.44) | |||
| OATP1B1 521 T > C | T/T | 13 (0.72) | T | 0.83 |
| T/C | 4 (0.22) | C | 0.17 | |
| C/C | 1 (0.06) | |||
| OATP1B1 diplotype | *1a/*1a | 3 (0.17) | ||
| *1a/*1b | 4 (0.22) | |||
| *1b/*1b | 6 (0.33) | |||
| *1a/*15 | 3 (0.17) | |||
| *1b/*15 | 1 (0.06) | |||
| *15/*15 | 1 (0.06) | |||
N = 18