Table 2.
Univariate and multivariate Cox regression analyses of clinical characteristics associated with overall survival
| Characteristics | Total (N) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| Age | 373 | ||||
| ≤ 60 | 177 | Reference | |||
| > 60 | 196 | 1.205 (0.850–1.708) | 0.295 | ||
| Gender | 373 | ||||
| Female | 121 | Reference | |||
| Male | 252 | 0.793 (0.557–1.130) | 0.200 | ||
| Pathologic stage | 349 | ||||
| Stage I & Stage II | 259 | Reference | |||
| Stage III & Stage IV | 90 | 2.504 (1.727–3.631) | < 0.001 | 1.341 (0.182–9.864) | 0.773 |
| Histologic grade | 368 | ||||
| G1&G2 | 233 | Reference | |||
| G3&G4 | 135 | 1.091 (0.761–1.564) | 0.636 | ||
| DDX1 | 373 | ||||
| Low | 186 | Reference | |||
| High | 187 | 1.628 (1.145–2.313) | 0.007 | 1.822 (1.139–2.915) | 0.012 |
| AFP(ng/ml) | 279 | ||||
| ≤ 400 | 215 | Reference | |||
| > 400 | 64 | 1.075 (0.658–1.759) | 0.772 | ||
| T stage | 370 | ||||
| T1&T2 | 277 | Reference | |||
| T3&T4 | 93 | 2.598 (1.826–3.697) | < 0.001 | 1.833 (0.248–13.569) | 0.553 |
| N stage | 258 | ||||
| N0 | 254 | Reference | |||
| N1 | 4 | 2.029 (0.497–8.281) | 0.324 | ||
| M stage | 272 | ||||
| M0 | 268 | Reference | |||
| M1 | 4 | 4.077 (1.281–12.973) | 0.017 | 1.856 (0.427–8.075) | 0.410 |
| Child-Pugh grade | 240 | ||||
| A | 218 | Reference | |||
| B&C | 22 | 1.643 (0.811–3.330) | 0.168 | ||
| Residual tumor | 344 | ||||
| R0 | 326 | Reference | |||
| R1&R2 | 18 | 1.604 (0.812–3.169) | 0.174 | ||
| Tumor status | 354 | ||||
| Tumor free | 202 | Reference | |||
| With tumor | 152 | 2.317 (1.590–3.376) | < 0.001 | 1.873 (1.172–2.995) | 0.009 |
Bold values indicates p < 0.05