Table 1.
Suggestive associations (P < 1E−5) observed for aTRH
| CHR | SNP | Imputed or genotyped | BP | RA | NRA | OR | L95 | U95 | P value | Nearest gene | MAF-case | MAF-control |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1p35 | rs7542771 | Imputed | 31237122 | T | C | 0.588 | 0.465 | 0.743 | 8.76E−06 | LAPTM5-SDC3 | 0.150 | 0.210 |
| 1p35 | rs10798802 | Imputed | 31243913 | T | C | 0.578 | 0.456 | 0.732 | 5.30E−06 | 0.147 | 0.209 | |
| 1p35 | rs11299707 | Imputed | 31246659 | AC | A | 0.586 | 0.464 | 0.742 | 8.33E−06 | 0.150 | 0.211 | |
| 1p35 | rs878465 | Imputed | 31247089 | A | G | 0.588 | 0.465 | 0.744 | 9.34E−06 | 0.150 | 0.211 | |
| 1p35 | rs10798803 | Imputed | 31247334 | A | C | 0.588 | 0.465 | 0.744 | 9.34E−06 | 0.150 | 0.211 | |
| 1p35 | rs10798804 | Imputed | 31247358 | T | C | 0.588 | 0.465 | 0.744 | 9.34E−06 | 0.150 | 0.211 | |
| 1p35 | rs6668307 | Imputed | 31247514 | G | T | 0.588 | 0.465 | 0.744 | 9.34E−06 | 0.150 | 0.211 | |
| 1p35 | rs6659862 | Imputed | 31247540 | T | C | 0.588 | 0.465 | 0.744 | 9.34E−06 | 0.150 | 0.211 | |
| 1p35 | rs4949297 | Imputed | 31247674 | C | A | 0.588 | 0.465 | 0.744 | 9.34E−06 | 0.150 | 0.211 | |
| 1p35 | rs4949179 | Imputed | 31247811 | A | T | 0.588 | 0.465 | 0.744 | 9.34E−06 | 0.150 | 0.211 | |
| 1p35 | rs4949298 | Imputed | 31247991 | A | G | 0.588 | 0.465 | 0.744 | 9.34E−06 | 0.150 | 0.211 | |
| 1p35 | rs10798805 | Imputed | 31248289 | G | T | 0.588 | 0.465 | 0.744 | 9.34E−06 | 0.150 | 0.211 | |
| 1p35 | rs10753235 | Imputed | 31248432 | A | C | 0.588 | 0.465 | 0.744 | 9.34E−06 | 0.150 | 0.211 | |
| 1p35 | rs10753236 | Imputed | 31248435 | G | T | 0.588 | 0.465 | 0.744 | 9.34E−06 | 0.150 | 0.211 | |
| 4q13.2-21.1 | rs1432330 | Imputed | 70513551 | G | A | 1.553 | 1.290 | 1.869 | 3.33E−06 | UGT2A1 | 0.414 | 0.342 |
| 4q13.2-21.1 | rs4148279 | Genotyped | 70514358 | C | T | 1.563 | 1.298 | 1.884 | 2.61E−06 | 0.412 | 0.340 | |
| 4q13.2-21.1 | rs4148277 | Imputed | 70514829 | T | A | 1.560 | 1.295 | 1.879 | 2.75E−06 | 0.413 | 0.342 | |
| 4q13.2-21.1 | rs7672805 | Imputed | 70516520 | G | A | 1.560 | 1.295 | 1.879 | 2.75E−06 | 0.413 | 0.342 | |
| 4q13.2-21.1 | rs10000435 | Imputed | 70516671 | C | T | 1.563 | 1.297 | 1.884 | 2.71E−06 | 0.417 | 0.343 | |
| 4q13.2-21.1 | rs1432332 | Imputed | 70517108 | C | T | 1.580 | 1.311 | 1.905 | 1.61E−06 | 0.416 | 0.341 | |
| 5q22-23.2 | rs1876648 | Genotyped | 121027720 | A | G | 1.581 | 1.318 | 1.898 | 8.38E−07 | LOC102467226-FTMT | 0.475 | 0.394 |
| 5q22-23.2 | rs10056108 | Imputed | 121028770 | A | T | 1.571 | 1.309 | 1.886 | 1.24E−06 | 0.476 | 0.396 | |
| 15q11.1-q12 | rs7181789 | Genotyped | 23043896 | A | G | 1.529 | 1.273 | 1.837 | 5.45E−06 | NIPA1 | 0.487 | 0.423 |
Chr chrom genome version of CRCh37/hg19, Chr chromosome, SNP single-nucleotide polymorphism, BP base position, RA risk allele, NRA non-risk allele, OR odds ratio, L95 lower 95% limit, U95 upper 95% limit, MAF Minor allele frequency