Table III.
Genotype and allele distribution of the APOA1 and APOB polymorphisms in NID and DI groups
| 75 G>A Genotype APOA1 | NID n = 85 (%) | DI n = 130 (%) | OR (CI) | P-value |
|---|---|---|---|---|
| G/G | 50 (58.8) | 58 (44.6) | – | – |
| G/A | 27 (31.8) | 63 (48.5) | 2.01 (1.117–3.623) | 0.019 |
| A/A | 8 (9.4) | 9 (6.9) | 0.970 (0.348–2.702) | 0.042 |
| Alleles: | 2n = 170 (%) | 2n = 260 (%) | ||
| G | 127 (74.7) | 179 (68.8) | – | – |
| A | 43 (25.3) | 81 (31.2) | 1.33 (0866–2063) | 0.19 |
| Models*: | ||||
| Dominant: | ||||
| G/G | 50 (58.8) | 58 (44.6) | – | – |
| G/A + A/A | 35 (41.2) | 72 (55.4) | 1.77 (1.020–3.084) | 0.042 |
| Recessive: | ||||
| G/G + G/A | 77 (90.6) | 121 (93.1) | – | – |
| A/A | 8 (9.4) | 9 (6.9) | 0.716 (0265–1935) | 0.50 |
| 83 C>T Genotype APOA1 | NID n = 80 (%) | DI n = 135 (%) | OR (CI) | P-value |
| C/C | 67 (83.8) | 123 (91.1) | – | – |
| C/T | 13 (16.2) | 12 (8.9) | 0.503 (0.217–1.164) | 0.10 |
| T/T | 0 (0.0) | 0 (0.0) | 0.547 (0.011–27.85) | 1.00 |
| Alleles: | 2n = 160 (%) | 2n = 270 (%) | ||
| C | 147 (87.5) | 258 (95.6) | – | – |
| T | 13 (12.5) | 12 (4.4) | 0.526 (0.234–1.183) | 0.11 |
| 2488 C>T Genotype APOB | NID n = 82 (%) | DI n = 135 (%) | OR (CI) | P-value |
| C/C | 32 (39.0) | 56 (41.5) | – | – |
| C/T | 36 (43.9) | 60 (44.4) | 0.909 (0.642–1.287) | 0.59 |
| T/T | 14 (17.1) | 19 (14.1) | 0.701 (0.425–1.156) | 0.16 |
| Alleles: | 2n = 164 (%) | 2n = 270 (%) | ||
| C | 100 (61.0) | 172 (63.7) | – | – |
| T | 238 (39.0) | 98 (36.3) | 0.89 (0.597–1.734) | 0.56 |
DI – infarcted diabetics (cases), NID – non-infarcted diabetics (controls), CI – confidence interval, OR – odds ratio.
*
Models are shown only for 75 G> A polymorphism due to the association found between genotypes.