Table 2.

Adverse events and laboratory abnormalities

	(280 mg/m2/4 hours)			(380 mg/m2/4 hours)
	(n=6)			(n=1)
Events	Grade 1	Grade 2	Grades 3–5	Grade 1	Grade 2	Grades 3–5
Common adverse events
Nasopharyngitis	0	0	0	1 (100%)	0	0
Open angle glaucoma	0	1 (17%)	0	0	0	0
Haemorrhage	0	1 (17%)	0	0	0	0
Abdominal discomfort	2 (33%)	0	0	0	0	0
Constipation	1 (17%)	0	0	0	0	0
Diarrhoea	1 (17%)	0	0	0	0	0
Nausea	1 (17%)	0	0	0	0	0
Vomiting	1 (17%)	0	0	0	0	0
Hepatic function abnormal	1 (17%)	1 (17%)	0	0	1 (100%)	0
Dermatitis contact	1 (17%)	0	0	0	0	0
Dry skin	0	1 (17%)	0	0	0	0
Back pain	0	1 (17%)	0	0	0	0
Renal impairment	1 (17%)	0	0	0	0	0
Fever	1 (17%)	0	0	1 (100%)	0	0
Infusion site extravasation	0	1 (17%)	0	0	0	0
Tooth fracture	1 (17%)	0	0	0	0	0