Table 3.

Pharmacokinetic parameters for OP-724 and C-82 after OP-724 infusion

		OP-724				C-82
Dose		Tmax	Cmax	AUC0-24h	T1/2(h)	Tmax	Cmax	AUC0-24h	T1/2(h)
(mg/m2/4 hours)		(h)	(ng/mL)	(ng･h/mL)		(h)	(ng/mL)	(ng･h/mL)
280	N	6	6	6	4	6	6	6	6
	Mean	1.9	1850	6420	0.438	2.8	2020	10 700	3.51
	SD	1.2	510	1910	0.107	1.3	390	2400	0.84
	CV(%)	63.2	27.6	29.8	24.4	46.4	19.3	22.4	23.9
	Min	0.5	1080	3880	0.336	1	1350	7070	2.45
	Max	4	2460	9210	0.588	4	2310	13 500	4.73
	Median	2	2000	6340	0.414	3	2220	11 200	3.5
380	N	1	1	1	1	1	1	1	1
	Mean	1	3980	10 200	0.497	2	2370	12 600	3.45

For the calculation of AUC_{0–24 hours}, BLQ were assumed as 0 ng/mL.

AUC, area under curve; BLQ, Below the Limit of Quantitation.