Table 4.
Modified HAI score, CPA, MELD score, CP score, liver stiffness measure and ELF score after OP-724 treatment
| Patient ID | Age | Time point | Modified HAI score | Collagen proportional area | MELD score | Child-Pugh score | FibroScan (kPa) | ELF score | |||||
| Interface hepatitis | Confluent necrosis | Lobular inflammation | Portal inflammation | HAI score | Stage | Sirius red positive area (%) | |||||||
| P101-01 | 66 | Baseline | 2 | 0 | 1 | 3 | 6 | 4 | 7.8010627 | 15 | 6 | 9.1 | 1.2 |
| 12 weeks | 2 | 0 | 1 | 3 | 6 | 3 | 2.7389579 | 15 | 7 | 8.9 | 0.9 | ||
| P101-02 | 73 | Baseline | 2 | 0 | 2 | 2 | 6 | 5 | 4.9477138 | 2 | 6 | 40.3 | 0.78 |
| 12 weeks | 1 | 0 | 1 | 1 | 3 | 5 | 3.7144629 | 2 | 6 | 33.8 | 0.24 | ||
| P101-04 | 68 | Baseline | 2 | 0 | 1 | 1 | 4 | 3 | 6.8891091 | 6 | 7 | 26.3 | 2.46 |
| 12 weeks | 3 | 1 | 2 | 3 | 9 | 5 | 7.5842215 | 8 | 7 | 23.6 | 3.16 | ||
| P101-07 | 67 | Baseline | 2 | 2 | 3 | 3 | 10 | 3 | 3.8731926 | 5 | 5 | 11.6 | −0.1 |
| 12 weeks | 2 | 0 | 2 | 2 | 6 | 3 | 3.6462028 | 5 | 5 | 9.2 | −0.07 | ||
| P101-08 | 52 | Baseline | 4 | 3 | 3 | 3 | 13 | 5 | 7.7587483 | 6 | 6 | 22.3 | 0.96 |
| 12 weeks | 1 | 0 | 3 | 2 | 6 | 2 | 3.4838244 | 6 | 6 | 36.3 | 1.48 | ||
CPA, collagen proportionate area; CP score, Child-Pugh score; ELF, The Enhanced Liver Fibrosis; HAI, Histological Activity Index; MELD, Model for End-stage Liver Disease.