Tab. II.
In vivo and in vitro study samples about the effects of some polyphenolic compounds on cancer development. In the last column, a downward-facing arrow means that the compound is known to induce a reduction, while an upward-facing arrow means that the compound is known to induce an increase.
| Reference | Polyphenolic compound | Results |
|---|---|---|
| [46] | Resveratrol (in vitro) |
On colon cancer cells: -Apoptosis ↑ -Proliferation ↓ -Angiogenesis ↓ |
| [47] | Resveratrol (in vitro) |
On glioblastoma cells: -Growing ↓ -Migration ↓ -Proliferation ↓ |
| [48] | Resveratrol (in vivo and in vitro) |
In female rats: -Breast tumor incidence ↓ On breast epithelial cells: -Anti-oxidant activities ↑ -Apoptosis ↑ -Migration ↓ |
| [49] | Resveratrol (in vivo and in vitro) |
Both on mice and on follicular thyroid cancer cells: -Tumorigenesis ↓ |
| [50] | Quercetin (in vitro) |
On glioblastoma cells: -Cell death ↑ |
| [51] | Quercetin (in vivo and in vitro) |
In female rats: -Tumor volume ↓ (both colon carcinoma and breast cancer cells) On colon carcinoma, prostate adenocarcinoma, pheochromocytoma, breast cancer, acute lymphoblastic leukemia T, myeloma, lymphoid Raji, and ovarian cancer cells: -Apoptosis ↑ -Cell death ↑ |
| [52] | Myricetin (in vitro) |
On breast cancer cells: -Apoptosis ↑ |
| [53] | Myricetin (in vitro) |
On prostate cancer cells: -Metastasis ↓ -Cytotoxicity ↑ -Apoptosis ↑ |
| [54] | Anthocyanins from bilberry (in vitro) |
On colon cancer cells: -Mitochondrial damage ↑ -Apoptosis ↑ -Proliferation ↓ |
| [55] | Anthocyanins from blueberry (in vitro) |
On melanoma cells: -Proliferation ↓ -Apoptosis ↑ |
| [56] | Oleocanthal (in vitro) |
On lung cancer cells: -Progression ↓ -Metastasis ↓ |
| [57] | Olive oil phenols (in vitro) |
On bladder cancer cells: -Apoptosis ↑ -Proliferation ↓ |
| [58] | Rosmarinic acid (in vitro) |
On melanoma cells: -Metastasis ↓ -Invasion ↓ -Proliferation ↓ -Apoptosis ↑ -Chemoprotective drug sensitivity ↑ |
| [59] | Naringenin (in vitro) |
On lung cancer cells: -Migration ↓ -Invasion ↓ -Proliferation ↑ -Apoptosis ↑ |
| [60] | Tannins (in vivo) |
In rats: -Antioxidant capacity ↑ |
| [61] | Some phenolic acids (in vitro) |
On breast cancer cells: -Apoptosis ↑ -Proliferation ↓ |
| [62] | Gallic acid (in vitro) |
On lung cancer cells, in combination with cisplatin (chemo drug): -Proliferation ↓ -Apoptosis ↑ |
| [63] | β-resorcylic acid lactones (in vitro) | On lung adenocarcinoma and colorectal cancer cells: -Cytotoxicity ↑ -Proliferation ↓ |