Tab. V.

Effect of phosphatidylserine on neurological conditions.

Neurological conditions	Subjects	Nutrients	Findings	References
Alzheimer’s disease	Aged patients with AD and dementia	Soy lecithin-derived phosphatidylserine plus phosphatidic acid	Improved cognition, mood, and memory	[58]
Attention deficit hyperactivity disorder (ADHD)	Children with ADHD	Phosphatidylserine	Improved short-term auditory memory and ADHD symptoms	[59]
Premenstrual syndrome (PMS)	40 women age 18-45 years diagnosed with PMS	400 mg PS + 400 mg PA per day or a matching placebo	Significant reduction in PMS symptoms	[60]
Cognitive impairment	Elderly persons with impaired memory	100 mg/day phosphatidylserine enriched with docosahexaenoic acid (PS-DHA)	May improve or maintain cognitive status	[61]
Cognitive function improvement	Elderly persons with impaired memory without dementia	Phosphatidylserine enriched with docosahexaenoic acid (PS-DHA)	May improve cognitive performance	[62]
Acute cognitive effects	Healthy young volunteers	Ginkgo biloba extract with soy-derived PS	Significantly improved memory task speed and improved secondary memory	[63]
Cognition and cortical activity after mental stress	Healthy subjects doing cognitive tasks under induced stress in a test–re-test design	Phosphatidylserine supplementation	Continued supplementation significantly was connected with a more relaxed state compared to the controls	[64]
Age-related cognitive function	130 elderly persons with cognitive impairment	PS derived from soybean 300 mg/day	Safely improved cognitive function	[65]
	494 elderly persons with cognitive impairment	300 mg/day PS supplements	Improved cognitive function in 6 months	[66]