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. 2022 Oct 17;63(2 Suppl 3):E12–E20. doi: 10.15167/2421-4248/jpmh2022.63.2S3.2741

Tab. I.

Some important phytochemicals and bioactive constituents of garlic.

Types Percent (g/ 100 gW) Bioactive Compounds Bioactivities Therapeutic effects References
Sulphur-containing compounds 2.3% Thiosulphinates like allicin, allylmethyl-, methylallyl- and trans-1-propenyl-thiosulfinate Allicin inhibits the growth of Staphylococcus aureus, Salmonella typhimurium, Escherichia coli, Bacillus cereus, Helicobacter pylori, and Streptococcus thermophilus Antimicrobial, urease inhibition [11, 12]
OrganoSulphur volatiles, including Diallyl disulfides (DADS), Diallyl sulfides (DAS), Diallyly trisulfides (DATS), sulfur dioxide, E/Z-ajoene, S-allyl-cysteine (SAC), and S-allyl-cysteine sulfoxide (alliin), S-allyl mercapto cysteine (SAMC) SAC AND SAMC have strong radical scavenging activities, DAS and DADS enhance the activity of glutathione reductase Antioxidants, prevent damage caused by free radicals, anti-cancer [13, 14]
Vinyldithiins including 2-vinyl-4H-1,3 dithiin Lowers platelet aggregation Antioxidants, cardioprotective, prevent myocardial infarction and ischemic stroke, reduce the risk of gastric and colon cancer [15,16]
Phenols 1.5% β-resorcylic acid, pyrogallol, protocatechuic acid, gallic acid, rutin, and quercetin Scavenge free radicals, relax coronary arteries, prevent myocardial Antioxidants, cardioprotective effects [17, 18]
Non-sulphur containing saponins β-cholorogenin, diosgenin, desgalactotigonin-rhamnose, proto-desgalactotigonin-rhamnose, voghieroside D1, sativoside B1-rhamnose, and sativoside R1 gitogenin and proto-desgalactotigonin Inhibit fungal pathogens, protect against reactive oxygen species, prevent DNA damage Antifungal, antitumor, antithrombotic, and cholesterol-lowering effects [14, 19]
Amino acids 1.2 % Arginine, leucine, glutamic acid, and aspartic acid Arginine is a precursor of neurotransmitter nitric oxide, they smooth muscle relaxation and lower blood pressure Neurotransmission, antihypertensive [20]