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. 2022 Aug 9;75(11):2000–2011. doi: 10.1093/cid/ciac284

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© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

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Figure 3. — The expression of HIV receptors CCR5 and α4β7 on Th17 target cells in women randomized to the Cu-IUD (n = 23; red), DMPA-IM (n = 20; blue), or LNG implant (n = 15; green). (A) The frequency of CCR5+ Th17 before and after initiation of contraception. (B) The cross-sectional comparison of CCR5+ Th17 frequency post-contraceptive initiation across study arms. (C) The MFI of CCR5 on Th17 cells before and after initiation of contraception. (D) The cross-sectional comparison of CCR5 MFI post-contraceptive initiation across study arms. (E) The frequency of α4β7+ Th17 cells before and after initiation of contraception. (F) The cross-sectional comparison of α4β7+ Th17 frequency post-contraceptive initiation across study arms. (G) The MFI of α4β7 on Th17 cells before and after initiation of contraception. (H) The cross-sectional comparison of α4β7 MFI post-contraceptive initiation across study arms. Th17 cells were defined as CD4+ CCR6+ CCR10−. The horizontal bars indicate the median. Statistical comparisons were performed using the Wilcoxon matched-pairs tests for matched data or the Kruskal-Wallis with false discovery rate correction for cross-sectional comparisons. Abbreviations: Cu-IUD, copper T intrauterine device; DMPA-IM, intramuscular depot medroxyprogesterone acetate; LNG, 2-rod levonorgestrel; MRI, median fluorescent intensity; Th17, T-helper 17.