Table 1.
Safe acute headache and migraine preventive medication in pregnancy and breastfeeding
| Medication | Pregnancy | Breastfeeding |
|---|---|---|
| Acute medication | ||
| Paracetamol | ✓ | ✓ |
| NSAIDs | ✓Stop by 30 weeks | ✓ |
| Aspirin (600 900 mg) | ✗ | ✓ |
| Opiates | ✓Use sparingly | ✓ Use sparingly |
| Triptans (for example, sumatriptan) | ✓ | ✓ |
| Anti-emetics | ||
| Cyclizine | ✓ | ✗ |
| Prochlorperazine | ✓ | ✓ Use sparingly |
| Ondansetron | ✓ | ✗ |
| Domperidone | ✓ | ✓ |
| Metoclopramide | ✓ | ✓ Use sparingly |
| Migraine preventives | ||
| Amitriptyline | ✓ | ✓ |
| Propranolol | ✓ | ✓ |
| Candesartan | ✗ | ✓With caution in early newborns |
| Topiramate | ✗ | ✓ |
| Pizotifen | ✗ | ✗ |
NSAID = non-steroidal anti-inflammatory drug.