FIG. 4.

Structural organization of the HBD-2 gene and other selected antimicrobial peptide genes. The HBD-2 gene was cloned from a human genomic bacteriophage library. The sequence of 4.8 kb of DNA encompassing the gene was determined from each complementary strand. Intron-exon boundaries were defined based on comparison with the published cDNA sequence. Putative enhancer binding sites were identified by using MacVector software. The organization of the HBD-2 gene was compared with those of the TAP gene (9) and two inducible antimicrobial peptide genes from insects, acidic attacin (46) and diptericin (28).