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. 2022 Nov 22;11:e83743. doi: 10.7554/eLife.83743

Figure 5. The movements of the dehydrogenase (DH) domain from the resting NOX2 to the active DUOX1.

Figure 5.

(A) Side view of the structural alignment of NOX2 in the resting state (light blue) and DUOX1 in the high-calcium state (yellow) in cartoon representation. Their transmembrane domains (TMD) were used in alignment. The rotation axis of DH domains is shown in dark blue. The rotational and translational movements from the DH domain of NOX2 to the DH domain of DUOX1 are indicated with arrows. (B) Bottom view of A. (C) The centers of mass of FAD molecules in the resting NOX2 and in the active DUOX1 are shown as spheres and the movement of FAD is indicated by an arrow.