Figure 6. Phage-immunoprecipitation sequencing (PhIP-seq) screening of multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD) cohorts.

(A) Heatmap of signal for putative hits from Gruber et al., 2020, among MIS-C, adult COVID-19 controls, and pediatric febrile controls (each n=20). (B) Only rare, shared PhIP-seq signals were found among n=20 MIS-C patients. (C) Heatmap of putative antigens in a cohort of n=70 KD patients. Hits that are specific to KD and are not found among n=20 febrile controls, are highlighted in green. (D) A small number of rare putative antigens are shared between KD and MIS-C (left), with radioligand binding assay confirmation of antibody reactivity to whole protein form of CGNL1 in three KD patients and one MIS-C patient (right).