Table 4.
Association of Peri-Infection Anti-Spike IgG Values With Risk for COVID-19 Diagnosis
| Anti-Spike IgG Threshold | N | Person-Days at Risk | COVID-19 Diagnoses | Rate per 10,000 d | OR (95% CI) |
|
|---|---|---|---|---|---|---|
| Unadjusted | Adjusted | |||||
| <1 | 2,515 | 164,908 | 55 | 3.34 | 2.60 (1.72-3.94) | 2.41 (1.46-3.98) |
| 1-<2 | 854 | 38,964 | 15 | 3.85 | 2.97 (1.62-5.42) | 2.60 (1.22-5.56) |
| 2-<7 | 1,844 | 67,836 | 23 | 3.39 | 2.58 (1.54-4.35) | 2.49 (1.37-4.53) |
| 7-<10 | 528 | 21,302 | 5 | 2.35 | 1.78 (0.70-4.56) | 1.28 (0.39-4.24) |
| ≥10 | 7,042 | 293,817 | 39 | 1.33 | 1.00 (reference) | 1.00 (reference) |
| Total | 12,783 | 586,827 | 137 | 2.33 | – | – |
N indicates number of individuals contributing to time at risk. Each anti-spike IgG group OR was adjusted using a multivariable logistic model that included age, sex, race, diabetes, dialysis modality, congregate living status, dialysis adequacy, albumin, hepatitis B virus seroimmunity, disability, comorbidity, number of and specific comorbidities (diabetes, chronic obstructive pulmonary disease, chronic heart failure, hypertension, peripheral vascular disease, cancer, alcohol or drug abuse), immunocompromised status, and 75th percentile of county SARS-CoV-2 infection rate to account for geotemporal variability in the intensity of the epidemic. Abbreviations: IgG, immunoglobulin G; OR, odds ratio.