Table 5.
Association of Peri-Infection Anti-Spike IgG Values With Risk for COVID-19–Related Hospitalization or Death
| Anti-Spike IgG Threshold | N | Person-Days at Risk | Events ≤30 d From COVID-19 Diagnosis | Rate per 10,000 Days | OR (95% CI) |
|
|---|---|---|---|---|---|---|
| Unadjusted | Adjusted | |||||
| <1 | 2,515 | 165,750 | 21 | 1.27 | 1.98 (1.06-3.70) | 1.43 (0.67-3.05) |
| 1-<2 | 854 | 39,037 | 6 | 1.54 | 2.39 (0.95-6.03) | 2.50 (0.90-6.92) |
| 2-<7 | 1,844 | 68,312 | 4 | 0.59 | 0.90 (0.31-2.66) | 0.50 (0.12-2.19) |
| 7-<10 | 528 | 21,344 | 2 | 0.94 | 1.45 (0.34-6.27) | 0.77 (0.10-5.82) |
| ≥10 | 7,042 | 293,652 | 19 | 0.65 | 1.00 (reference) | 1.00 (reference) |
| Total | 12,783 | 588,095 | 52 | 0.88 | – | – |
N indicates no. of individuals contributing to time at risk. Each anti-spike IgG group OR was adjusted using a multivariable logistic model that included age, sex, race, and 75th percentile of county SARS-CoV-2 infection rate to account for geotemporal variability in the intensity of the epidemic. Abbreviations: IgG, immunoglobulin G; OR, odds ratio.