Table 3.
Associations between menstrual cycle characteristics and epithelial ovarian cancer among women in the Ovarian Cancer in Women of African Ancestry (OCWAA) consortium by race, menopausal status and histotype
| Black | White | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls | HGS Cases |
Other Histotype Cases |
HGS | Other Histotype |
hist. p-het |
Controls | HGS Cases |
Other Histotype Cases |
HGS | Other Histotype |
hist. p-het |
|
| N (%) | N (%) | N (%) | aOR (95 % CI) | aOR (95 % CI) | N (%) | N (%) | N (%) | aOR (95 % CI) | aOR (95 % CI) | |||
| Age at Menarche | ||||||||||||
| Overall | ||||||||||||
| <11 years | 231 (9.9) | 62 (9.6) | 39 (10.5) | 1.09 (0.74, 1.62) | 1.15 (071, 1.84) | 0.98 | 450 (6.0) | 113 (6.4) | 85 (7.5) | 1.29 (0.98, 1.71) | 1.18 (0.86, 1.62) | 0.24 |
| 11-12 years | 978 (42.1) | 248 (38.2) | 168 (45.0) | 1.12 (0.83, 1.51) | 1.26 (0.88, 1.82) | 3077 (40.8) | 730 (41.1) | 476 (42.1) | 1.20 (0.99, 1.46) | 1.03 (0.82, 1.28) | ||
| 13-14 years | 830 (35.7) | 259 (39.9) | 121 (32.4) | 1.26 (0.94, 1.70) | 1.05 (0.72, 1.53) | 3241 (43.0) | 764 (43.0) | 449 (39.7) | 1.20 (0.99, 1.45) | 0.96 (0.77, 1.20) | ||
| 15+ years | 286 (12.3) | 80 (12.3) | 45 (12.1) | Reference | Reference | 776 (10.3) | 170 (9.6) | 122 (10.8) | Reference | Reference | ||
| P-trend | 0.92 | 0.21 | 0.11 | 0.23 | ||||||||
| Meno. p-het | 0.87 | 0.90 | 0.05 | 0.09 | ||||||||
| Premenopausal | ||||||||||||
| <11 years | 77 (11.3) | 18 (12.6) | 15 (12.6) | 1.16 (0.54, 2.50) | 1.18 (0.52, 2.70) | 0.99 | 69 (5.9) | 22 (8.6) | 29 (9.3) | 2.58 (1.26, 5.30) | 1.97 (1.06, 3.66) | 0.38 |
| 11-12 years | 314 (46.2) | 62 (43.4) | 57 (47.9) | 1.09 (0.59, 2.01) | 1.19 (0.61, 2.29) | 479 (40.9) | 116 (45.5) | 139 (44.7) | 1.89 (1.07, 3.32) | 1.39 (0.86, 2.23) | ||
| 13-14 years | 212 (31.2) | 45 (31.5) | 33 (27.7) | 1.18 (0.62, 2.24) | 1.05 (0.52, 2.12) | 495 (42.3) | 101 (39.6) | 118 (37.9) | 1.66 (0.94, 2.93) | 1.19 (0.74, 1.93) | ||
| 15+ years | 77 (11.3) | 18 (12.6) | 14 (11.8) | Reference | Reference | 127 (10.9) | 16 (6.3) | 25 (8.0) | Reference | Reference | ||
| P-trend | 0.87 | 0.56 | 0.01 | 0.02 | ||||||||
| Postmenopausal | ||||||||||||
| <11 years | 154 (9.4) | 44 (8.7) | 24 (9.5) | 1.06 (0.67, 1.68) | 1.15 (0.64, 2.07) | 0.97 | 381 (6.0) | 91 (6.0) | 56 (6.8) | 1.11 (0.82, 1.51) | 0.99 (0.68, 1.43) | 0.23 |
| 11-12 years | 664 (40.4) | 186 (36.8) | 111 (43.7) | 1.16 (0.82, 1.64) | 1.33 (0.86, 2.07) | 2598 (40.8) | 614 (40.3) | 337 (41.1) | 1.11 (0.90, 1.37) | 0.93 (0.73, 1.20) | ||
| 13-14 years | 618 (37.6) | 214 (42.3) | 88 (34.7) | 1.32 (0.94, 1.86) | 1.09 (0.69, 1.71) | 2746 (43.1) | 663 (43.6) | 331 (40.3) | 1.15 (0.93, 1.41) | 0.90 (0.70, 1.16) | ||
| 15+ years | 209 (12.7) | 62 (12.3) | 31 (12.2) | Reference | Reference | 649 (10.2) | 154 (10.1) | 97 (11.8) | Reference | Reference | ||
| P-trend | 0.87 | 0.25 | 0.68 | 0.99 | ||||||||
| Age at Regularity | ||||||||||||
| Overall | ||||||||||||
| <11 years | 147 (9.0) | 44 (8.0) | 28 (8.9) | 0.92 (0.60, 1.42) | 1.04 (0.61, 1.75) | 0.77 | 292 (4.3) | 92 (5.5) | 73 (6.8) | 1.31 (0.98, 1.74) | 1.39 (1.01, 1.92) | 0.83 |
| 11-12 years | 599 (36.5) | 196 (35.5) | 140 (44.6) | 1.12 (0.82, 1.52) | 1.42 (0.98, 2.06) | 2275 (33.3) | 630 (37.7) | 415 (38.9) | 1.25 (1.06, 1.49) | 1.20 (0.98, 1.48) | ||
| 13-14 years | 596 (36.3) | 230 (41.7) | 101 (32.2) | 1.33 (0.98, 1.80) | 1.12 (0.76, 1.64) | 2910 (42.6) | 713 (42.6) | 426 (39.9) | 1.24 (1.05, 1.47) | 1.12 (0.92, 1.38) | ||
| 15+ years | 299 (18.2) | 82 (14.9) | 45 (14.3) | Reference | Reference | 1348 (19.8) | 238 (14.2) | 154 (14.4) | Reference | Reference | ||
| P-trend | 0.53 | 0.21 | 0.03 | 0.02 | ||||||||
| Meno. p-het | 0.38 | 0.61 | 0.15 | 0.26 | ||||||||
| Premenopausal | ||||||||||||
| <11 years | 49 (11.7) | 11 (9.5) | 11 (10.9) | 0.74 (0.31, 1.75) | 1.24 (0.49, 3.11) | 0.26 | 61 (5.3) | 18 (7.3) | 27 (8.9) | 2.20 (1.10, 4.37) | 2.17 (1.20, 3.91) | 0.62 |
| 11-12 years | 186 (44.4) | 45 (38.8) | 47 (46.5) | 0.86 (0.46, 1.61) | 1.55 (0.76, 3.17) | 424 (37.1) | 107 (43.3) | 129 (42.7) | 1.79 (1.11, 2.88) | 1.50 (0.99, 2.27) | ||
| 13-14 years | 113 (27.0) | 40 (34.5) | 31 (30.7) | 1.33 (0.70, 2.56) | 1.82 (0.86, 3.88) | 474 (41.5) | 97 (39.3) | 110 (36.4) | 1.52 (0.94, 2.45) | 1.20 (0.79, 1.82) | ||
| 15+ years | 71 (17.0) | 20 (17.2) | 12 (11.9) | Reference | Reference | 183 (16.0) | 25 (10.1) | 36 (11.9) | Reference | Reference | ||
| P-trend | 0.21 | 0.74 | 0.01 | 0.004 | ||||||||
| Postmenopausal | ||||||||||||
| <11 years | 98 (8.0) | 33 (7.6) | 17 (8.0) | 1.00 (0.60, 1.66) | 1.02 (0.53, 1.95) | 0.82 | 231 (4.1) | 74 (5.2) | 46 (6.0) | 1.15 (0.83, 1.57) | 1.17 (0.79, 1.72) | 0.78 |
| 11-12 years | 413 (33.8) | 151 (34.6) | 93 (43.7) | 1.26 (0.88, 1.79) | 1.47 (0.94, 2.28) | 1851 (32.6) | 523 (36.7) | 286 (37.3) | 1.18 (0.98, 1.42) | 1.12 (0.88, 1.42) | ||
| 13-14 years | 483 (39.5) | 190 (43.6) | 70 (32.9) | 1.39 (0.99, 1.96) | 0.99 (0.63, 1.55) | 2436 (42.9) | 616 (43.2) | 316 (41.3) | 1.21 (1.01, 1.45) | 1.11 (0.88, 1.40) | ||
| 15+ years | 228 (18.7) | 62 (14.2) | 33 (15.5) | Reference | Reference | 1165 (20.5) | 213 (14.9) | 118 (15.4) | Reference | Reference | ||
| P-trend | 0.93 | 0.15 | 0.26 | 0.35 | ||||||||
All models are adjusted for site, age, education, young adult weight, and height