Table 2.
Overall data from AXIS tool conducted studies ∗. Calculated relative risk (RR), 95% CI and P values investigating the efficacy of FN from the oral microbiome and its biomarker potential for breast cancer in adult women.
| Type of analysis | No. of studies | Heterogeneity | Results | |||
|---|---|---|---|---|---|---|
| P | I 2(%) | RR | 95% CI | P value | ||
| Overall analysis (articles included from AXIS tool analysis only) | 6 | 0.03 | 50.89 | 1.28 | 1.03–1.45 | <0.01 |
| Study design | ||||||
| Prospective cohort | 4 | 0.08 | 43.24 | 1.18 | 0.95–1.40 | 0.07 |
| Retrospective cohort | 1 | 0.35 | 40.65 | 1.22 | 1.11–1.39 | <0.01 |
| Case-control | 1 | — | — | 2.10 | 1.15–2.78 | 0.04 |
| Follow-up period∗∗ | ||||||
| <10 years | 3 | 0.55 | 0.73 | 1.18 | 1.15–1.29 | <0.01 |
| ≥10 years | 2 | 0.05 | 65.94 | 1.41 | 0.88–1.87 | 0.06 |
| Dental status | ||||||
| PD | 6 | 0.04 | 51.74 | 1.24 | 1.01–1.30 | 0.04 |
∗ CASP-Tool examined articles were omitted due to insufficient statistical data. ∗∗ 1 Article omitted due to absence of follow-up period.