Figure 1.

Time course and inflammation changes after intra-articular injection of CFA in rats. (a) Time course and procedures of CFA and inhibitor administration. (b) Representative changes of the synovium and condylar cartilage in the control and inflammatory tissues under H&E staining. (i) Synovium: proliferated synovial lining featured villous hyperplasia into cavity in OA group. (ii) Compared to the sham-treated group, mandibular condyle: proliferative layer, maturation layer, and hypertrophic layer were thinned in the OA group.