Table 1.
Baseline characteristics, biomarkers, 6-minute walk test, echocardiographic and cardiovascular magnetic resonance parameters for patients who had amyloid regression, stable findings or progression by cardiovascular magnetic resonance at 6 months
| Characteristics | Regression (N = 4) | Stable (N = 92) | Progression (N = 46) |
|---|---|---|---|
| Men, n (%) | 2 (50%) | 58 (63%) | 26 (57%) |
| Age (years) | 45 (16) | 65 (10)* | 63 (11)** |
| NT-proBNP (pmol/L) | 250 (146–296) | 2418 (858–5184)* | 3730 (883–6544)** |
| 6MWT (m) | 476 (153) | 409 (135) | 401 (131) |
| Echocardiographic parameters | |||
| IVS (cm) | 1.07 (SD 0.06) | 1.45 (SD 0.24)* | 1.44 (SD 0.25)** |
| LVEDD (cm) | 3.77 (SD 0.21) | 4.15 (SD 0.56) | 4.12 (SD 0.54) |
| LAA (cm2) | 14.23 (4.80) | 21.45 (SD 5.64) | 20.46 (SD 4.72) |
| E/E’ | 9 (SD 5) | 16 (SD 7) | 16 (SD 7) |
| 2D LS | −20.8 (SD 4.5) | −13.8 (SD 4.8)* | -14.1 (SD 5.3) |
| CMR parameters | |||
| LVEDVi (mL/m2) | 59 (SD 18) | 69 (SD 15) | 63 (SD 11) |
| LVESVi (mL/m2) | 17 (SD 7) | 25 (SD 11) | 22 (SD 8) |
| Maximal IVS (mm) | 11 (SD 1) | 16 (SD 4) | 16 (SD 4) |
| LV mass index (g/m2) | 60 (SD 19) | 99 (SD 32)* | 98 (SD 29) |
| LVSVi (mL/m2) | 43 (SD 11) | 44 (SD 10) | 41 (SD 9) |
| LVEF (%) | 73 (SD 4) | 64 (SD 9) | 65 (SD 10) |
| LAA (cm2) | 18 (SD 4) | 28 (SD 8)* | 27 (SD 5)** |
| RA area (cm2) | 16 (SD 3) | 23 (SD 7) | 24 (SD 6) |
| MAPSE (mm) | 11 (SD 3) | 8 (SD 3) | 9 (SD 3) |
| TAPSE (mm) | 21 (SD 4) | 16 (SD 5) | 16 (SD 6) |
| Native T1 (ms) | 1157 (SD 50) | 1151 (SD 64) | 1152 (SD 51) |
| T2 (ms) | 54 (SD 6) | 53 (SD 3) | 53 (SD 3) |
| ECV (%) | 41 (SD 4) | 47 (SD 7) | 45 (SD 7) |
6MWT, 6-minute walk test; AL, systemic light-chain; CMR, cardiovascular magnetic resonance; CR: complete (haematological) response, DT, deceleration time; ECV, extracellular volume; LS, longitudinal strain; IVS, interventricular septum; LAA, left atrial area; LPW, left posterior wall; LV, left ventricle; LVEDD, left ventricular end-diastolic diameter; LVEDV/LVEDVi, left ventricular end-diastolic volume/index; LVEF, left ventricular ejection fraction; LVESV/LVESVi, left ventricular end-systolic volume/indexed; LVSV/LVSVi, left ventricular stroke volume/index; LVEF, left ventricular ejection fraction; NR, no (haematological) response; NT-proBNP, N-terminal pro-B-type natriuretic peptide; PR, partial (haematological) response; TAPSE, tricuspid annular plane systolic excursion; VGPR, very good partial (haematological) response.
All continuous variables are presented as mean and standard deviation apart from NT-proBNP which is presented as median and interquartile range. Natural log-transformed NT-proBNP was used for parametric testing, but in this table the raw data is summarized by the median and interquartile range.
P-values for pairwise comparison:
P < 0.05 for regression vs. stable
P < 0.05 for regression vs. progression.