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. 2022 Dec 1;23:438–470. doi: 10.1016/j.bioactmat.2022.11.014

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 16 — CTCE decorated p53 mRNA-nanoparticles restore the expression of encoded p53 protein in HCCs, secreting multiple cytokines that modulate immune cells for efficacious cancer treatment. (a) Illustrated are the composition of synthetic CTCE-p53 NPs and the mechanism of CTCE-p53 NPs evoking strong anti-tumor response. (b) A representative TEM image of CTCE-p53 NPs. (c) Immunofluorescence images of p53 knockout RIL-175 cells showed the expression of encoded p53 (scale bar: 50 μm). (d, e) p53 null RIL-175 tumor growth curves (d), and the percentages of tumor infiltrating CD3⁺CD8⁺ T cells and M2-like macrophages (e) of mice treated with different formulations as indicated [35]. Reproduced under the terms of the Creative Commons CC BY license. Copyright 2022, The Author(s), published by Springer Nature.