Fig. 9.

mRNA-sugar-capsule decorated with mannan or dextran promotes DC maturation via the activation of multiple pattern recognition receptors, cross-presentation of translated antigens, thus elicits effective anti-tumor T cell response. (a) Illustrated is the preparation process of mRNA-sugar-capsule. (b) Representative TEM images of sugar-capsules. (c) Cy5.5 signal intensity of Cy5.5 (cyanine5.5) tagged Man-capsule or Dex-capsule in inguinal and axiliary LNs harvested from C57BL/6 mice post injection. (d) The experimental timeline of mouse B16F10-OVA model and the average tumor growth curves of mice received with different formulations. (e) Flow cytometry data showing the frequency of tumor-infiltrating OVA specific tetramer + CD8⁺ T cells. Reprinted with permission from Ref. [158]. Copyright 2020, American Chemical Society.