FIG. 2.

Survival after Th1- and Th2-polarized immunizations and virulent T. cruzi challenge. Mice were immunized with T. cruzi lysate with no bias, Th1 bias, or Th2 bias, similar to the experiments described in the legend for Fig. 1. Each mouse received three vaccinations 2 weeks apart. The Th1 and Th2 groups received the cytokine-antibody treatments with the first two vaccinations. All immunized mice received only parasite lysate with the third vaccination. Two weeks after the last vaccination, mice were challenged with virulent T. cruzi BFT. Cumulative survival is shown for each group (n = 5 mice/group) from one experiment representative of three separate experiments. Tc, T. cruzi.