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. 2022 Oct 26;612(7938):106–115. doi: 10.1038/s41586-022-05249-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Total copy number (top) and HSCN (bottom) profiles for two single cells from a case of TNBC HRD-Dup (SA501) and a case of HGSC FBI (SA1049). b, Total copy number heat map (left) and HSCN heat map (right) for 1,283 cells from SA1049. c,d, Proportion of polyploid cells (c) and cells with missegregation events (d). e, Ratio of chromosomal gains versus losses across different ploidy states and mutational signature groupings (number of cells shown below each violin plot). All box plots indicate the median, first and third quartiles (hinges), and the most extreme data points no farther than 1.5× the IQR from the hinge (whiskers).