Table 2.
Objective 2, meta-regression analysis of the effect of BMC strategies on (A) locomotor recovery and (B) in vivo axonal regeneration; combinations tested in vitro and/or in vivo.
| A Improvement in locomotor outcomes | ||||
|---|---|---|---|---|
| Biomaterial-based combination | Effect size (%) | P > | t | | 95% Conf. Interval | Frequency % (n) |
| PLGA + combinations | 41.5 | 0.064 | [16.7, 66.3] | 4.9 (5) |
| Chitosan + combinations | 27.3 | 0.289 | [10.2, 44.4] | 13.7 (14) |
| HA + combinations | 22.5 | 0.684 | [1.1, 43.9] | 6.9 (7) |
| Collagen + combinations | 18.1 | 0.002 | [6.9, 29.2] | 22.6 (23) |
| Fibrin + combinations | 14.8 | 0.703 | [−2.1, 31.7] | 13.6 (14) |
| Other biom. + combinations | 30.7 | 0.064 | [17, 44.4] | 37.9 (39) |
| comparisons=102, p = 0.142, Tau2 = 520.7, I2 = 97.7%, adj R2 = 4.11% | ||||
| B Improvement in axonal regeneration | ||||
|---|---|---|---|---|
| Biomaterial-based combination | Effect size (SD) | P > | t | | 95% Conf. Interval | Frequency % (n) |
| Chitosan + combinations | 2.9 | 0.235 | [0.9, 4.8] | 6 (7) |
| PLGA + combinations | 2.8 | 0.289 | [0.7, 4.8] | 5.1 (6) |
| LOCS + combinations | 2.4 | 0.391 | [0.7, 4.0] | 6.8 (8) |
| Alginate + combinations | 1.9 | 0.838 | [−0.4, 4.1] | 4.27 (5) |
| Collagen + combinations | 1.7 | 0.001 | [0.8, 2.5] | 24 (28) |
| Matrigel + combinations | 1.4 | 0.836 | [−0.6, 3.5] | 4.3 (5) |
| Fibrin + combinations | 0.3 | 0.067 | [−1.2, 1.8] | 8.5 (10) |
| Fibrin-PLGA + combinations | −0.1 | 0.078 | [−2, 1.8] | 5.1 (6) |
| Other biom. + combinations | 1.6 | 0.853 | [0.5, 2.7] | 35.9 (42) |
| comparisons = 117, p = 0.182, Tau2 = 2.2, I2 = 76.2%, adj R2 = 9.3% | ||||
PLGA poly(lactic-co-glycolic-acid), HA hyaluronic acid, LOCS linear ordered collagen scaffold.