Figure 1.

Hierarchical clustering of patients based on their radiomic profiles and the corresponding clinical values at baseline, 6 months, and 12 months follow-up.

Patient hierarchical clustering dendrograms were created based on the radiomic profiles of the patients at a) baseline, b) 6 months and c) 12 months. Red indicates the value of the given clinical parameter, with red corresponding to the highest value and white corresponding to the lowest value among the individuals. Low cophenetic correlation values between the dendrograms at baseline and 6 months (cophenetic correlation=0.42) and 6 months and 12 months (cophenetic correlation=0.67) indicate substantial changes in radiomic features which result in reorganization of patient similarities.

Abbreviations: ASCVD: atherosclerotic cardiovascular risk, CP: calcified plaque, LANCP: low-attenuation noncalcified plaque, NCP: noncalcified plaque