Table 9.
Baseline MP-OCT overlay metrics, overall and by clinical diagnosis and disease duration.
| All | Clinical Diagnosis | P-value | Disease durationb | P-value | ||||
|---|---|---|---|---|---|---|---|---|
| N | USH2 | ARRP | <10 | 10–20 | ≥20 | |||
| N= 83 | N=51 | N=32 | N= 29 | N=34 | N=19 | |||
| Average sensitivity within Intact EZ Area | 0.17 | 0.08 | ||||||
| Median (Q1, Q3) | 23 (21, 25) | 22 (21, 25) | 24 (22, 25) | 22 (21, 25) | 24 (22, 25) | 20 (18, 24) | ||
| Average sensitivity (interpolated) within intact EZ area | 0.13 | 0.02 | ||||||
| Median (Q1, Q3) | 21 (19, 24) | 21 (18, 23) | 22 (20, 24) | 21 (19, 24) | 21 (20, 23) | 18 (15, 23) | ||
| Average sensitivity outside intact EZ area | 0.80 | 0.02 | ||||||
| Median (Q1, Q3) | 2 (1, 6) | 2 (1, 7) | 2 (2, 5) | 4 (2, 8) | 2 (1, 4) | 3 (1, 5) | ||
| Average sensitivity (interpolated) outside intact EZ Area | 0.64 | 0.01 | ||||||
| Median (Q1, Q3) | 2 (1, 5) | 2 (1, 5) | 2 (1, 4) | 3 (2, 6) | 1 (1, 3) | 2 (0, 4) | ||
| Number of pixels within intact EZ area within the interpolated microperimetry map a | 0.03 | <0.001 | ||||||
| Median (Q1, Q3) | 21 (10, 43) | 16 (6, 36) | 24 (14, 60) | 37 (23, 62) | 16 (10, 34) | 7 (3, 16) | ||
| Number of pixels outside intact EZ area within the interpolated microperimetry map a | 0.04 | <0.001 | ||||||
| Median (Q1, Q3) | 713 (691, 724) | 718 (699, 728) | 710 (675, 720) | 696 (673, 711) | 718 (701, 725) | 728 (715, 731) | ||
| Number of sensitivity points within intact EZ area | 0.03 | <0.001 | ||||||
| Median (Q1, Q3) | 5 (3, 9) | 4 (2, 8) | 6 (4, 12) | 9 (5, 12) | 4 (2, 7) | 2 (1, 4) | ||
| Ratio of average sensitivity (interpolated) inside vs outside intact EZ | 0.11 | 0.95 | ||||||
| Median (Q1, Q3) | 8 (3, 16) | 6 (2, 15) | 11 (5, 17) | 6 (3, 13) | 16 (4, 18) | 6 (3, 13) | ||
a
Different scale (all values reported have been divided by 1000)
b
1 participant in the ARRP group was missing age of onset (a participant-reported field based on their awareness of visual symptoms) and duration of disease (computed based on age of onset and date of enrollment