TABLE 3.

Studies on the therapeutic effect of in vivo NG2 cell and neural progenitor cell reprogramming on SCI.

Somatic cell	Subject	Induction method	Cell type	Achievements	References
NG2 cell	Mouse	PD168393 (EGF receptor inhibitor)	Neurons	NG2 cells were converted to neurons in vitro; the number of neurons was increased, and the neurobehavioral performance of SCI model mice was improved	Ju et al., 2012
NG2 cell	Mouse	Lentivirus-mediated transcription factor (Sox2)	Neurons	In an SCI model, NG2 cells were converted to mature neurons, formed synaptic connections, reduced scar tissue formation and promoted functional recovery	Tai et al., 2021
Neural progenitor cell	Rat	Retrovirus-mediated transcription factors (Ascl1 and Ngn2) combined with growth factors	Neurons (Ngn2 with growth factor); oligodendrocytes (Ascl1 with growth factor)	In an SCI model, neural progenitor cells were converted to neurons (mainly GABAergic neurons) and oligodendrocytes in situ	Ohori et al., 2006