FIGURE 4.

Prioritization of disease genes by topological character in the network and DEG in COPD. Plot of miRNA, mRNA, and protein with their log2 fold change in COPD vs. healthy (x-axis) and smoker vs. healthy (y-axis). The color and node size correspond to their bottleneck values in the Integrative Network. The symbols of the top 10 miRNAs, mRNAs, and proteins with the highest bottleneck values are labeled (the full node characters in the network and differentially expressed tests are provided in Supplementary Table S2). VCP: valosin-containing protein; YWHAZ: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta; CALU: calumenin; SNX6: sorting nexin 6; M6PR: mannose-6-phosphate receptor, cation-dependent; IER3IP1: immediate early response 3-interacting protein 1; SPCS3: signal peptidase complex subunit 3; RAP2B: RAP2B, member of the RAS oncogene family; STX7: syntaxin 7; AIFM1: apoptosis-inducing factor mitochondria-associated 1; ATP6V1A: ATPase H+-transporting V1 subunit A; Q9UNH7: sorting nexin 6; UGGT1: UDP-glucose:glycoprotein glucosyltransferase 1; RAB8A: Ras-related protein Rab-8A; GOT2: glutamic oxaloacetic transaminase 2; QKI: quaking; VAPA: virulence-associated protein A; VPS26A: vacuolar protein sorting-associated protein 26a; CAST: calpastatin.