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. 2022 Nov 17;13:1010048. doi: 10.3389/fgene.2022.1010048

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Copyright © 2022 Li, Gao, Sköld and Wheelock.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Let-7-AIFM1-FKBP1A pathway and its potential effect in COPD. The let-7 family has an increased correlation with AIFM1 protein expression in COPD, which may induce a stronger inhibition than through the ROS and mTOR pathway to influence autophagy and cell differentiation in COPD. AIFM1: apoptosis-inducing factor mitochondria-associated 1, FKBP1: FKBP prolyl isomerase 1A, MTDH: metadherin, ASPH: aspartate β-hydroxylase, UGGT1: UDP-glucose:glycoprotein glucosyltransferase 1, ROS: reactive oxygen species, mTOR: mammalian target of rapamycin, COPD: chronic obstructive pulmonary disease. Created using BioRender.com.