TABLE 4.
Treatment-related AEs (TRAEs).
| Adverse event | Chemotherapy | TKIs + chemotherapy | TKIs + ICIs | |||
|---|---|---|---|---|---|---|
| All grade | ≥ Grade3 | All grade | ≥ Grade3 | All grade | ≥ Grade3 | |
| Hematologic | ||||||
| Decreased white blood count | 38 (62.3) | 6 (9.8) | 29 (61.7) | 5 (10.6) | 3 (5.6) | 0 |
| Decreased neutrophil count | 38 (62.3) | 5 (8.2) | 29 (61.7) | 5 (10.6) | 3 (5.6) | 0 |
| Anemia | 18 (29.5) | 2 (3.3) | 16 (34.0) | 1 (2.1) | 8 (14.8) | 0 |
| Decreased platelet | 8 (13.1) | 0 | 6 (12.8) | 0 | 6 (11.1) | 0 |
| Increased ALT/AST | 10 (16.4) | 1 (1.6) | 9 (19.1) | 1 (2.1) | 5 (9.3) | 0 |
| Hypercholesterolemia | 4 (6.6) | 0 | 4 (8.5) | 0 | 5 (9.3) | 0 |
| Hypertriglyceridemia | 4 (6.6) | 0 | 3 (6.4) | 0 | 8 (14.8) | 0 |
| LDL elevation | 2 (3.3) | 0 | 3 (6.4) | 0 | 6 (11.1) | 0 |
| TSH elevation | 0 | 0 | 0 () | 0 | 11 (20.4) | 0 |
| Non-hematologic | ||||||
| Fatigue | 16 (26.2) | 0 | 17 (36.2) | 0 | 20 (37.0) | 0 |
| Nausea or Vomiting | 20 (32.8) | 2 (3.3) | 14 (29.8) | 1 (2.1) | 2 (3.7) | 0 |
| Diarrhea | 11 (18.0) | 1 (1.6) | 8 (17.0) | 0 | 2 (3.7) | 0 |
| Muscle pain/joint pain | 18 (29.5) | 0 | 8 (17.0) | 1 (2.1) | 0 | 0 |
| Sensory neurotoxicity | 20 (32.8) | 2 (3.3) | 10 (21.3) | 0 | 0 | 0 |
| Secondary hypertension | 0 | 0 | 13 (27.7) | 1 (2.1) | 20 (37.0) | 5 (9.3) |
| Hand-foot syndrome | 0 | 0 | 12 (25.5) | 3 (6.4) | 16 (29.6) | 3 (5.6) |
| Proteinuria | 0 | 0 | 10 (21.3) | 0 | 13 (24.1) | 0 |
| Rash | 2 (3.3) | 0 | 6 (12.8) | 0 | 14 (25.9) | 1 (1.9) |
| Pneumonitis | 0 | 0 | 0 () | 0 | 5 (9.3) | 1 (1.9) |
| Oral mucositis | 4 (6.6) | 0 | 3 (6.4) | 0 | 6 (11.1) | 0 |
| Hypothyroidism | 0 | 0 | 0 () | 0 | 11 (20.4) | 0 |
| Gum bleeding | 0 | 0 | 4 (8.5) | 0 | 3 (5.6) | 0 |
AE, adverse event.