FIGURE 3.

CBMC TRQ module and LPS‐stimulated IL‐6 production co‐associate with childhood asthma development. (A) CBMC TRQ eigengene values and IL‐6 responses to LPS stimulation at birth are significantly correlated. Red and black dots represent neonates with or without a diagnosis of asthma during childhood, respectively. (B) Interaction between TRQ module methylation (eigengene value), LPS‐induced IL‐6 responses at birth, and prevalence of asthma during childhood. p for interaction was assessed using logistic regression. (C) The risk of childhood asthma is related to CBMC TRQ methylation status and IL‐6 responses. Odds ratios were calculated by logistic regression. For panels B and C, TRQ eigengene vector and z‐scored LPS‐stimulated IL‐6 production were each categorized into “High” and “Low” values, divided at zero.