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. 2022 Nov 17;13:1073243. doi: 10.3389/fmicb.2022.1073243

Table 2.

Activity of disorazol F2 (1) against human cancer cell lines (IC50, nM).

Compounds HepG2 HCT116 A549
F2 (1) 0.25 ± 0.01 3.11 ± 0.10 2.74 ± 0.56
Vincristine 6.62 ± 0.48 50.05 ± 3.68 44.28 ± 4.55
Doxorubicin 830 ± 119 793 ± 90 919 ± 35

IC50 values are calculated from three independent biological replicates.